ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0017.11-13 | Pharmacologic Treatment | ESPEYB17

11.13. Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

EA Day , RJ Ford , BK Smith , P Mohammadi-Shemirani , MR Morrow , RM Gutgesell , R Lu , AR Raphenya , M Kabiri , AG McArthur , N McInnes , S Hess , G Pare , HC Gerstein , GR Steinberg

To read the full abstract: Nat Metab 2019;1:1202–1208.Metformin has become a mainstay in the treatment of T2DM in over six decades of clinical use and is today one of the world’s most commonly prescribed drugs. Anti-diabetic properties of metformin rely on an inhibition of hepatic glucose output through AMPK-dependent, but also AMPK-independent effects (reviewed in (1)). Neverthel...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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